Figure 1.

Effects of LCN2 deletion on insulin resistance in HFD/STZ-induced diabetic mice: (A) body weights, (B) fasting serum glucose levels, and (C) serum insulin levels for each group; (D) representative images showing H&E-stained pancreatic sections; scale bar = 50 µm; (E) pancreatic islet areas measured for each group; (F) serum LCN2 levels measured for each group. CTL: control; DM: diabetic mice. Data are presented as the mean ± SEM. The indicated p-values represent a two-way ANOVA, followed by Tukey’s post hoc test. * p < 0.05 vs. WT CTL. ^† p < 0.05 vs. WT DM.