Table 1.

Transcription factor-based biosensors.

Types	Analytes	Genetic Systems		Output Elements	Refs
		Bacterial Strains	TFs
Whole-cell biosensors	Cu(II)Ag(I)	E. coli	CueR	luxCDABE	[42]
	Pb(II)Hg(II)Zn(II)Cd(II)	E. coli	ZntR	luxCDABE/eGFP	[42,43]
	As(III)As(V)	E. coli	ArsR	Luciferase/β-galactosidase/ GFP	[44,45]
	Benzoate	P. putida	BenR	GFP	[46]
	Malonyl-CoA	B. subtilis	FapR	eGFP	[47]
	BTEX (benzene, toluene, ethylbenzene, xylene)	R. Pickettii	TbuT	GFP	[48]
	Sodium Dodecyl Sulfate(SDS)	P. aeruginosa	SdsB1	GFP	[49]
	Lactate	E. coli	LldR	GFP	[50]
	Homogenitisic Acid	P. aeruginosa	HmgR	GFP	[51]
	2,4-diacetylphloroglucinol(DAPG)	P. fluorescens	PglF	LacZ/ luxCDABE	[52]
	Salicylate	P. putida	NahR	luciferase	[53]
	Trans-cinnamic Acid	E. coli	HcaR	eYFP	[54]
	Caprolactam	A. faecalis	NitR	sfGFP	[55]
	Salicylic acid	E. coli	MarR	eGFP	[56]
Cell-free biosensors	Hg(II)	S. flexneri	MerR	sfGFP	[57]
	γ-hydroxybutyrate	A. tumefaciens	BlcR	sfGFP	[57]
	Tetracycline	E. coli	TetR	ROSALIND:Transcript-fluorophore complex	[58]
	Oxytetracycline	S. rimosus	OtrR
	Erythromycin	E. coli	MphR
	3-hydroxy benzoic acid	C. testosteroni	MobR
	Zn(II)	S. elongatus	SmtB
	Cu(I), Cu(II)	B. subtilis	CsoR
	Cd(II)	S. aureus	CadC
	Pb(II)	S. aureus	CadC
	As(III)	E. coli	ArsR	ArsR-GFP released from immobilized DNA upon As(III)	[59]
	Benzoic acidHg(II)As(III)	E. coli	BenRMerRArsR	eGFP	[60]