Table 4.
Laboratory parameters in asthmatic patients and control subjects.
| Patients n = 74 |
Controls n = 65 |
p-Value | |
|---|---|---|---|
| Basic laboratory tests | |||
| Hemoglobin, g/dL | 13.5 (13–14.4) | 13.9 ± 1.28 | 0.09 |
| Red blood cell count, 106/μL | 4.61 ± 0.43 | 4.6 ± 0.38 | 0.83 |
| White blood cell count, 103/μL | 6.68 (5.6–7.96) | 5.48 (4.82–6.64) | <0.001 ** |
| Eosinophils, 103/μL | 275 (135–470) | 15 (9–80) | <0.001 ** |
| Monocytes, 103/μL | 600 (485–815) | 480 (430–670) | <0.001 ** |
| Blood platelets, 103/μL | 218 (191–247) | 232 (203–293) | 0.01 * |
| C-reactive protein, mg/L | 2.55 (0.58–8.67) | 1 (0.9–1.7) | 0.04 * |
| Immunoglobulin E, IU/mL | 71.5 (29.4–380) | 22.6 (18.5–53.5) | 0.001 * |
| Glucose, mmol/L | 5 (4.65–5.55) | 5.17 ± 0.54 | 0.63 |
| Total cholesterol, mmol/L | 4.83 ± 0.98 | 4.8 (4.25–5.35) | 0.74 |
| Low-density lipoprotein cholesterol, mmol/L | 2.61 ± 0.76 | 3.38 ± 0.96 | <0.001 ** |
| High-density lipoprotein cholesterol, mmol/L | 1.34 (1.09–1.61) | 1.58 ± 0.41 | 0.01 * |
| Triglycerides, mmol/L | 1.4 (1–2) | 1.09 (0.82–1.42) | <0.001 ** |
| Biomarkers in serum § | |||
| Interleukin-6, pg/mL | 0.78 (0.45–2.09) | 0.73 ± 0.52 | 0.31 |
| Interleukin-10, pg/mL | 0.57 (0.25–0.97) | 0.005 (0.005–0.01) | <0.001 ** |
| Interleukin-12(p70), pg/mL | 0.005 (0.005–1.3) | 0.005 (0.005–1.69) | 0.75 |
| Interleukin-17A, pg/mL | 0.005 (0.005–0.12) | 0.005 (0.005–0.06) | 0.87 |
| Interferon-γ, pg/mL | 0.005 (0.005–0.28) | 0.11 (0.005–0.27) | 0.66 |
| Citrullinated histone H3, ng/mL | 16.3 (10.7–19.8) | 12.8 (8.2–17.6) | 0.04 * |
Variables are presented as median and interquartile range, or mean and standard deviation, as appropriate. References: § all serum measurements of interleukin (IL)-4 and IL-5 were below the assay threshold (data not shown); ** p < 0.001; * p < 0.05 and p ≥ 0.001.