Table 2.
Levels of urine biomarkers between IC/BPS and control groups.
| IC/BPS | ||||||
|---|---|---|---|---|---|---|
| Urine Biomarkers @ | (A) ESSIC Type 1 N = 42 |
(B) ESSIC Type 2 N = 117 |
Overall N = 159 |
(C) Control N = 28 |
p-Value # | p-Value $ |
| 8-OHdG | 25.81 ± 18.44 (0) | 38.67 ± 18.68 * (0) | 35.27 ± 19.41 (0) | 18.33 ± 13.48 (0) | <0.001 | <0.001 |
| 8-isoprostane | 36.47 ± 26.4 * (0) | 44.32 ± 33.11 * (3) | 42.20 ± 31.56 (3) | 20.69 ± 21.15 (0) | 0.169 | <0.001 |
| TAC | 1641.8 ± 1317.2 (0) | 1597.4.2 ± 1226.0 (6) | 1610.6 ± 1247.5 (6) | 1119.4 ± 1064.1 (0) | 0.845 | 0.060 |
| MCP-1 | 237.57 ± 211.06 * (2) | 297.47 ± 276.06 * (3) | 281.91 ± 261.41 (5) | 142.25 ± 93.02 (1) | 0.214 | <0.001 |
| RANTES | 7.97 ± 8.00 (0) | 9.34 ± 8.21 * (1) | 8.97 ± 8.15 (1) | 5.34 ± 4.56 (1) | 0.354 | 0.001 |
| CXCL 10 | 25.76 ± 38.68 (1) | 41.04 ± 57.59 * (1) | 37.05 ± 53.61 (2) | 14.76 ± 18.63 (1) | 0.117 | <0.001 |
| Eotaxin | 8.25 ± 8.03 (1) | 8.52 ± 6.8 * (2) | 8.45 ± 7.12 (3) | 4.88 ± 3.21 (1) | 0.836 | <0.001 |
| MIP-1β | 2.82 ± 2.24 (1) | 2.65 ± 1.96 (2) | 2.69 ± 2.03 (3) | 2.44 ± 1.59 (0) | 0.635 | 0.533 |
| IL-8 | 11.71 ± 13.46 (1) | 11.45 ± 13.12 (2) | 11.52 ± 13.17 (3) | 14.62 ± 24.13 (1) | 0.914 | 0.520 |
Note: 8-OHdG, 8-hydroxy-2-deoxyguanosine; TAC, total antioxidant capacity; MCP-1, macrophage chemoattractant protein-1; RANTES, regulated upon activation, normal T cell expressed and presumably secreted; CXCL10, chemokine (C-X-C motif) ligand 10; MIP-1β, macrophage inflammatory protein 1β. (): indicates the number of outliers. *: p-values < 0.05 when compared with controls. #: p-values between ESSIC type 1 and type 2 IC/BPS patients. $: p-values between overall IC/BPS patients and controls. @: units: all pg/mL, except ng/mL in 8-OHdG, and mmol/μL in TAC.