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. 2022 Jun 24;12(7):881. doi: 10.3390/biom12070881

Figure 9.

Figure 9

The effects of (S)-MK-26 on effort-based choice using the FR5/chow and PROG/chow feeding choice task. For FR5/chow procedure, rats (n = 8) received i.p. injections of vehicle plus vehicle (V/VEH), 1.0 mg/kg TBZ plus vehicle (T/VEH), or TBZ plus 3.75, 7.5 mg/kg for the low-dose progression (A), and 15.0, 30.0, or 45.0 mg/kg for the high-dose progression (B) of (S)-MK-26. For PROG/chow procedure, rats (n = 15) received i.p. injections of vehicle (VEH), 15.0, 30.0, or 45.0 mg/kg doses of (S)-MK-26 (C). Top: Mean (±SEM) number of lever presses during the 30 min session. TBZ plus vehicle significantly differed from vehicle plus vehicle (# p < 0.001); TBZ plus 15.0 and 30.0 mg/kg of (S)-MK-26 (** p < 0.01); and TBZ plus 45.0 mg/kg of (S)-MK-26 (* p < 0.05). For PROG/chow schedule, 45.0 mg/kg (S)-MK-26 significantly differed from vehicle (* p < 0.05). Bottom: Mean (±SEM) gram quantity of chow intake. TBZ plus vehicle significantly differed from vehicle plus vehicle (# p < 0.001); TBZ plus 15.0, 30.0 and 45.0 mg/kg of (S)-MK-26 (** p < 0.01). For PROG/chow schedule, 30.0 and 45.0 mg/kg of (S)-MK-26 significantly differed from vehicle (* p < 0.05 and ** p < 0.01, respectively).