Table 2.
Overall assessment of the effect of (S)-MK-26 on DA concentrations in the NAc shell, NAc core and mPFC dialysate, as measured by the AUCs calculated from the data shown in Figure 4 and Figure 5. AUCs values are expressed as mean ± SEM. One-way ANOVA followed by Bonferroni’s multicomparison test. *: p < 0.05 vs. vehicle-treated rats; #: p < 0.05 vs. 1 mg/kg-treated rats.
| DA Concentrations (as Determined from AUCs) | ||||
|---|---|---|---|---|
| Treatment | Vehicle (Kolliphor 30%) 1.5 mL/kg |
(S)-MK-26 1 mg/kg |
(S)-MK-26 10 mg/kg |
|
| Brain Area | ||||
| NAc shell | 664 ± 525 | 2972 ± 1094 | 7730 ± 1389 *# | |
| NAc core | 276 ± 104 | 3056 ± 644 | 7861 ± 1697 *# | |
| mPFC | 530 ± 129 | 3159 ± 223 | 4983 ± 547 * | |