Table 1.
Body composition, food intake, and glycemic regulation in T2DM mice.
| GROUP | CON | DM | ||
|---|---|---|---|---|
| Median (Min, Max) | Mean (SD) | Median (Min, Max) | Mean (SD) | |
| Body weight (g) | ||||
| Initial body weight | 26.25 (24.12, 30.09) | 26.77 (1.67) | 30.02 (27.25, 30.05) | 30.4 (2.24) * |
| Final body weight | 34.84 (31.7, 39.38) | 35.23 (2.52) | 41 (33.97, 45.414) | 40.55 (3.46) * |
| Gain | 3.26 (2.48, 3.06) | 3.63 (0.96) | 5.69 (1.94, 7.67) | 5.32 (1.92) |
| % Fat | 29.40 (28.05, 41.39) | 31.61 (5.0) | 40.34 (32.55, 59.3) | 42.40 (9.07) * |
| % Lean | 67.65 (54.67, 68.9) | 65.31 (5.42) | 57.24 (37.13, 65.35) | 55.16 (9.56) * |
| Gastrocnemius weight (g/kg BW) |
0.54 (0.48, 0.59) | 0.54 (0.03) | 0.43 (0.35, 0.48) | 0.42 (0.039) * |
| Quadriceps weight (g/kg BW) |
0.72 (0.59, 0.75) | 0.71 (0.05) | 0.55 (0.43, 0.61) | 0.53 (0.05) * |
| Food Intake (g/day) | 2.73 (2.32, 3.23) | 2.72 (0.26) | 2.53 (2.03, 3.29) | 2.53 (0.34) |
| Fasting blood glucose level (mg/dL) | 143 (119, 173) | 146.36 (15.09) | 263 (177,439) | 291.63 (89.45) * |
| Plasma insulin (μU/mL) | 8.66 (5.59, 18.88) | 10.0 (4.07) | 13.88 (7.3, 49.93) | 22.49 (16.96) * |
| HbA1c % | 4.95 (4.7, 5.4) | 5.0 (0.24) | 5.7 (3.2, 6.95) | 5.55 (1.15) * |
| HOMA-IR (mmol/L × μU/mL) | 2.91 (2.14, 7.5) | 3.65 (1.7) | 12.96 (5.06, 39.54) | 16.01 (11.39) * |
All values are reported as mean and SD. The asterisk represents statistical significance of differences from * p < 0.05. n = 9 mice in each group. CON, normal control mice; DM, diabetes mellitus mice.