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(a) The top 20 mutated genes with high functional impact involved in colorectal cancer extracted from the ICGC Data Portal in three projects: Colon Adenocarcinoma—TCGA, US, Adenocarcinoma, non-Western (China), Rectum Adenocarcinoma—TCGA, US. https://dcc.icgc.org/ (accessed on 15 December 2021) (b) Significantly mutated genes in hypermutated and non-hypermutated tumors adopted from The Cancer Genome Atlas Network [7].
