Table 1.

Single cell RNA seq analysis in human cerebral vessels and atherosclerotic plaques.

Data ID	Population	Cells	The Focus of the Paper	Findings
Fernandez_2019 Carotid Artery Plaque Endarterectomy	6 patients	7.169 CD45+ cells	Immune cells in the plaques	T cell exhaustion and different IL-1 signaling patterns in symptomatic patients
Depuit_2020 Carotid Artery Plaque Endarterectomy	18 patients	3.282	All the cells in the plaques	IL12-IFNγ axis, an important feature of T-cell activation in the plaque
Pan_2020 Carotid Artery Plaque Endarterectomy	3 patients	8.867	Vascular smooth muscle cell	Retinoic acid signaling modulates SMC and atherosclerosis progression
Alencar_2020 Carotid Artery Plaque Endarterectomy	18 patients	1.287	Vascular smooth muscle cells	SMC phenotypic is regulated by Klf4 and Oct4
Alsaigh_2020 Carotid Artery Plaque Endarterectomy + Adjacent	3 patients	51.981	All the cells in the plaques	TNFa pathways are active in both endothelial and SMC
Slenders_2021 Carotid Artery Plaque Endarterectomy	38 patients	5.633	Genetic risk factors	New gene target in cerebrovascular disease: ESAM LMNA, SLC44A2.
Chou_2021 Carotid Artery Plaque Endarterectomy	7 patients	6.049	Vascular smooth muscle cells	HDAC9 modifies VSMC phenotype and immune cell recruitment in carotid disease
Winkler_2022 Large and small arteries and veins Epileptic patients that underwent lobectomy	5 patients	74.535	Normal human brain vasculature.	Cellular and molecular profiles of the adult human cerebrovasculature
Winkler_2022 arteriovenous malformation (AVM)	5 patients	106.853	Malformed human brain vasculature	AVM rupture is leaded by GPNMB+ monocytes