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. 2022 Jul 2;12(7):930. doi: 10.3390/biom12070930

Table 2.

MicroRNAs targeting PD-1 in liver diseases.

miRNA miRNA Expression Liver Disease Target Cells Preclinical Models Reference
miR-15a-5p downregulated HCC CD8+ T cells HepG2 cells [93]
miR-138 downregulated HCC, CHB 1, LC 2 CD3+ T cells Primary lymphocytes [95]
miR-374b downregulated HCC Cytokine-induced killer cells HepG2 cells, xenograft mouse [102]
miR-4717 downregulated CHB 1 Peripheral lymphocytes HepG2 cells [103]

1 CHB: chronic hepatitis B; 2 LC: liver cirrhosis.