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. 2022 Jun 30;12(7):871. doi: 10.3390/brainsci12070871

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Predicted local Distance Difference Test (lDDT) for the PURA WT and (b) PURA–Phe233del-predicted structure deletion per amino acid using five different models via AlpahFold2. Models show that the occurrence of the Phe233del affects between 220–320 amino acids (red arrow). (c) A 3D reconstruction of the transcriptional activator protein Pur-alpha (PURA; Uniprot: Q00577) from the WT sequence using AlphaFold, focusing on the surrounding area of the Phe233 amino acid (in magenta; magenta arrow). (d) A 3D reconstruction of the PURA–Phe233del. Note the distortion (61.3 Å vs. 64.3 Å) in PURA structural conformation after the p.Phe233del occurs.