Table 1.
MicroRNAs differentially expressed in OA resulting from potential impaired expression by neutrophils.
| miRNA | Effects/Interactions | Expression in OA | References |
|---|---|---|---|
| miR-9 | Targets IL-6, NF-ΚB1 and MMP-13 | Downregulated | [48,49] |
| miR-21 | Inhibits GDF5 | Upregulated | [50,51,52] |
| miR-29 | Represses SOX9; targets collagen type 1A1 | Upregulated | [50,51,52] |
| miR-30 | Inhibits autophagy; induces apoptosis | Upregulated | [42,46] |
| miR-36 | Induces expression of inflammatory factors and chemokines via NF-ΚB/A20 signaling | Upregulated | [53] |
| miR-92a | Inhibits histone deacetylase; involved in cartilage development and homeostasis | Downregulated | [50,54,55,56] |
| miR-95 | Involved in cartilage development and homeostasis | Downregulated | [55] |
| miR-99a | Targets FZD1, ITGB5, GDF6; enhances inflammation and apoptosis | Downregulated | [47] |
| miR-100 | Involved in cartilage homeostasis | Downregulated | [55] |
| miR-135b | Involved in chondrocyte proliferation and cartilage repair | Upregulated | [55,57] |
| miR-140 | Induce SOX9, suppress hypertrophy by targeting SMAD1; involved in proliferation and migration of chondrocytes | Downregulated | [50,54,55] |
| miR-141 | Inhibits bone resorption | Upregulated | [39] |
| miR-143 | Targets genes including SMAD3 and DCAKD | Upregulated | [47] |
| miR-146a | Reduces Type II collagen; enhances autophagy and pro-inflammatory cytokines, inhibits NF-ΚB pathway; targets Camk2d | Upregulated | [42,50,58] |
| miR-155 | Inhibits autophagy; overexpression reduces S100A8/19-P secretion of proinflammatory cytokines | Upregulated | [42,46,47] |
| miR-193a | Inhibit inflammation, apoptosis, and cartilage degradation mediators (MMP-3, MMP-13, and ADAMTS)-5; Targets SOX5 | Downregulated | [55] |
| miR-204 | Regulates osteogenesis by targeting Runx2 expression | Downregulated | [50,54] |
| miR-222 | Regulates MMP-13 and histone deacetylase 4; improves chondrogenesis | Downregulated | [50,54] |
| miR-320c | Enhances chondrogenesis by upregulating SOX9 and downregulating MMP-13 and Wnt/β-catenin pathway | Downregulated | [55] |
| miR-370/373 | Inhibits SHMT2 and MECP2 | Downregulated | [50,54] |
| miR-381 | Inhibits histone deacetylase | Downregulated | [50,54] |
| miR-490 | Increases expression of Runx2, and decreases SOX9 | Upregulated | [50,51,52] |
| miR-1271 | Enhances expression of MMP-3, MMP-13 and ADAMTS-4, and decreases levels of SOX9, COL2A1 and aggrecan | Upregulated | [50,51,52] |