. 2022 Jul 8;12(7):959. doi: 10.3390/biom12070959

Table 2.

Some drugs and inhibitors of ADAMTS (TBD: to be determined).

ADAMTS	Endogenous Inhibitor				Synthetic Inhibitor				Reference
1	Material	Category	Action type	Molecular target	Material	Category	Action type	Molecular target	[27]
	TIMP-2	Tissue inhibitor of metalloproteinase	Binding inhibition	3N-terminal globular domain of aggrecan (G1)	1,10-phenanthroline	Organic small molecule	Binding inhibition	Urin recognition site (RX(K/R)R) (33, 34)
	TIMP-3				EDTA
	TIMP-3				BB-94
2	TIMP-3	Tissue inhibitor of metalloproteinase	Binding inhibition	Sulfated glycosaminoglycans associated with ECM and cell surfaces	TBD				[216,217,218,219]
	Cu²⁺	Metal ion		Bound zinc blinding zone
	α−2 macroglobulin	Enzyme
	Paplin	Protein		Non-competitive inhibition
3	TIMP-3	Tissue inhibitor of metalloproteinase	Binding inhibition	Sulfated glycosaminoglycans associated with ECM and cell surfaces	TBD				[218]
3	Cu²⁺	Metal ion	Binding inhibition	Bound zinc blinding zone	TBD				[218]
4	TIMP-3	Tissue inhibitor of metalloproteinase	Binding inhibition	Glu1480–Gly1481 bond	Cis-1(S)2(R)-amino-2-indanol-based	Organic small molecule	Selective action	Water bridging, ring rigidity, pocket size, and shape	[217,220,221]
	α−2 macroglobulin	Enzyme		691GRGHAR	Metformin
	PTH1-34	Hormone		IGF/IGFBP	Losartan		Signal conditioning	TGF-β1
					β-Ecdysone			FOXO1/ADAMTS-4/5
					4,5-Dicaffeoylquinic Acid			NF-κB
	Matrix protein CCN1	Protein		TGF-β/CCN1	4,5-Dicaffeoylquinic Acid			NF-κB
5	Matrix protein CCN1	Protein	Binding inhibition	TGF-β/CCN1	Cis-1(S)2(R)-amino-2-indanol-based	Organic small molecule	Selective action	Water bridging, ring rigidity, pocket size, and shape	[217,220,221,222,223,224,225,226]
	TIMP-3	Tissue inhibitor of metalloproteinase		Glu1480–Gly1481 bond	Metformin	Organic small molecule
	α−2 macroglobulin	Enzyme		YESDVM690	4,5-Dicaffeoylquinic Acid	Organic acid	Signal conditioning	NF-κB
	PTH1-34	Hormone		IGF/IGFBP	Glycoconjugated arylsulfonamide		Binding inhibition	Exosite
					Losartan		Signal conditioning	TGF-β1
					β-Ecdysone		Signal conditioning	FOXO1/ADAMTS-4/5
					5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors		Binding inhibition	MicroM
7	TIMP-4	Tissue inhibitor of metalloproteinase	Binding inhibition	Active site zinc	Granulin-epithelin precursor	Protein	Binding inhibition Binding inhibition	Carboxy-terminal TSR motifs of ADAMTS7 and 12	[76,217,227,228]
	GEP	Protein		C-terminal thrombospondin motifs	JG23	Organic acid		IC, cut
	GEP	Protein		C-terminal thrombospondin motifs	EDV33	Organic acid		Combined with zinc ion
8	TBD				LIPUS	Pulse	Electrotherapy	ZNT-9	[229,230,231]
12	TIMP-4	Tissue inhibitor of metalloproteinase	Binding inhibition	Active site zinc	Granulin-epithelin precursor	Protein	Binding inhibition	Carboxy-terminal TSR motifs of ADAMTS7 and 12	[76,217,227,228]
	α2-M	Enzyme
	GEP	Protein		C-terminal thrombospondin motifs
14	TIMP-3	Tissue inhibitor of metalloproteinase	Binding inhibition	Sulfated glycosaminoglycans associated with ECM and cell surfaces	TBD				[218]
	Cu²⁺	Metal ion	Binding inhibition	Bound zinc blinding zone	TBD				[218]