Figure 4.
PCs modulate intestinal and mesenteric lymphangiogenesis. Representative immunostaining images and quantification showing the density of lymphatic vessels (stained brown) using LYVE1 antibody in sham-operated and portal hypertensive mice 14 days after PPVL in (A,B) distal intestine, (C,D) proximal intestine, (E,F) mesentery of Math1Δintestine and control mice, respectively. Black line indicates 20 µm magnification. Abbreviations: Math1Δintestine, Paneth cell depleted; PPVL, partial portal vein ligation; LYVE1, lymphatic vessel endothelial hyaluronan receptor 1; ns, not significant. Data are expressed as mean ± SD. n = 5 per group. * p < 0.05; ** p < 0.005; *** p < 0.001.