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. 2022 Jul 12;10(7):1680. doi: 10.3390/biomedicines10071680

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Dissemination pattern of the xenograft orthotopic model of advanced endometrial cancer generated in NSG mice and comparison of dissemination between models derived from CXCR4⁺ and CXCR4⁻AN3CA cells. Histology of liver, lungs and lymph nodes with possible metastatic colonization after hematoxilin-eosin (H&E) staining of tissue sections or using immunohistochemical staining for anti-human CXCR4 or anti-human vimentin. Note the dramatically higher sensitivity of the anti-human vimentin IHC staining, to spot single or clustered cancer cells in the mouse tissues as compared to anti-CXCR4 IHC or H&E-stained tissues. Bar: 100 µm.