. 2022 Jul 12;10(7):1680. doi: 10.3390/biomedicines10071680

Table 1.

Comparison of metastatic dissemination in advanced endometrial cancer orthotopic models derived from CXCR4⁺ or CXCR4^- AN3CA cells.

Inoculated Cell Line	Liver Mets					Lung Mets
	Total Foci		Single Cell Foci	Clustered Cells Foci		Invaded Tissue Area (%)
	Number	Area (µm²)	Number	Number	Area (µm²)	Invaded Tissue Area (%)
CXCR4^- AN3CA	10.2 ± 6.7 ^a	615.5 ± 429.5 ^b	9.4 ± 6.3	0.9 ± 0.5 ^c	4486.4 ± 2728.0	11.5 ± 4.2 ^d
CXCR4⁺ AN3CA	24.2 ± 8.3 ^a	2536.8 ± 1746.8 ^b	15.6 ± 6.5	9.7 ± 2.7 ^c	5305.0 ± 3517.9	26.1 ± 7.0 ^d

The xenograft orthotopic models of advanced endometrial cancer were generated in NSG mice by implantation of CXCR4⁺ or CXCR4^- AN3CA cells (n = 4/group). Results are reported as mean ± s.e.m. of number or area of metastatic foci per mouse counting medium power microscope fields (200×, 10 fields) in liver or lung sections, after IHC staining using anti-human vimentin. Assessment of the effect size between groups was performed using Cohen’s delta (d) test. ^a d = 0.92; ^b d = 0.75; ^c d = 2.3; ^d d = 1.26.