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. 2022 Jun 24;10(7):1497. doi: 10.3390/biomedicines10071497

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Dysregulated expression of mitoribosome components, PTCD1, and PTCD3 in ATII cells in emphysema. (A) The expression of mitoribosome 12S, 16S, and the junction 12S–16S rRNA was assessed using RT-PCR in ATII cells isolated from nonsmokers (NS), smokers (SM), and emphysema patients (EM). mRNA expression of PTCD1 and PTCD3 (B) and MRPS27 and MRPL48 (C) was assessed by RT-PCR. (D) MRPS27 and MRPL48 protein levels were evaluated by Western blotting. (E) Protein quantification by densitometry analysis and normalization to vinculin is shown. Data are presented as means ± s.e.m (N = 4–14 per group; * p < 0.05; ** p < 0.01; *** p < 0.001).