Table 1.

Gene expression in adult Sig1R KO mice brain.

Gene Name	Sigmar1	Pgrmc1	Tph2	Gabbr2	Drd1	Drd2	Dnajc14 (Drip78)
Protein Name	Sigma-1 Receptor	Sigma-2 Receptor	Tryptophan 5-Hydroxylase 2	GABA-B Receptor Subunit 2	D(1A) Dopamine Receptor	D(2) Dopamine Receptor	Dopamine Receptor Interacting Protein
Prefrontal cortex	-	1 ± 0.0	1.1 ± 0.1	1.1 ± 0.1	0.9 ± 0.2	0.7 ± 0.3	0.7 ± 0.2
Striatum	-	0.9 ± 0.1	1.5 ± 0.2	1.6 ± 0.3	1 ± 0.1	1 ± 0.2	1.1 ± 0.5
Hypothalamus	-	1 ± 0.1	0.9 ± 0.2	1 ± 0.1	1.1 ± 0.2	1 ± 0.1	0.6 ± 0.1
Midbrain	-	1.1 ± 0.2	0.8 ± 0.2	0.8 ± 0.1	1.8 ± 0.6	1 ± 0.1	1.1 ± 0.2
Hippocampus	-	0.8 ± 0.1	1.3 ± 0.2	0.9 ± 0.1	0.9 ± 0.1	0.9 ± 0.1	0.8 ± 0.0
Cortex	-	0.8 ± 0.3	1 ± 0.1	1.5 ± 0.2 *	0.7 ± 0.2	0.7 ± 0.3	1 ± 0.2

The relative expression levels for each gene were calculated with the ΔΔC_t method, normalized to the expression level of β-actin, and compared to the expression levels in WT control mice. Data are expressed as the mean fold change ± SEM (n = 8 mice/group). * p < 0.05 vs. WT mice; unpaired t-test.