Figure 1.

Differences in tau deposition to [¹⁸F]-AV1451 PET between participants with self-reported history of traumatic brain injury (TBI+) and those without TBI history (TBI-). (A) The statistical difference map of [¹⁸F]-AV1451 SUVr between the TBI+ group in contrast to the control group (TBI-/CDR = 0) group, showing that history of TBI increased the tau deposition in wide-spread brain regions. (B) The statistical difference map of [¹⁸F]-AV1451 SUVr in the symptomatic cases between the TBI+/CDR ≥ 0.5 (in contrast to TBI-/CDR ≥ 0.5) showed increased tau deposition in cortical regions overlapping with those reported for Alzheimer’s disease [40,41]. The statistical tests were corrected for nuisance covariates, including age, gender, education, and APOE-ε4 status. Red-yellow shows regions with the TBI+ group showing higher tau as compared to TBI-, while blue-green represents less tau deposition in the TBI+ as compared to TBI-.