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Silencing CCL4 expression inhibits tumor-induced angiogenesis in vivo. (A–C) Mice were injected subcutaneously with Matrigel OSCC CM for 14 days, after which time the plugs were excised, photographed and quantified for hemoglobin content (A), then stained with CD31 (B,C). (D–F) The tumor sections were immunostained using Angpt2 and CD31 antibodies. * p < 0.05 compared with controls.
