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. 2022 Jul 11;10(7):1661. doi: 10.3390/biomedicines10071661

Figure 3.

Figure 3

Semaglutide improves hypertension in db/db UNx-ReninAAV mice. (A) Diastolic arterial blood pressure. (B) Systolic arterial blood pressure. (C) Mean arterial blood pressure. Blood pressure was measured by tail cuff plethysmography in treatment week 1 and 10. Semaglutide monotherapy (30 nmol/kg, s.c, q.d., n = 15) and combination treatment with lisinopril (30 mg/kg, p.o., q.d., n = 14) was performed for 11 weeks in db/db UNx-ReninAAV mice. Vehicle-dosed (s.c, q.d.) db/db UNx-ReninAAV mice (n = 15) served as controls. ** p < 0.01, *** p < 0.001 vs. vehicle-dosed db/db UNx-ReninAAV mice. ## p < 0.01, ### p < 0.001 vs. semaglutide (Dunnett’s test one-factor/two-factor linear model with interaction).