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. 2022 Jul 11;10(7):1661. doi: 10.3390/biomedicines10071661

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Semaglutide improves urinary markers in db/db UNx-ReninAAV mice. (A) Urine albumin-to-creatine ratio (ACR). (B) Urine kidney molecule-1 (KIM-1)-to-creatine ratio. (C) Plasma urea concentrations. (D) Plasma cystatin C levels. Semaglutide monotherapy (30 nmol/kg, s.c, q.d., n = 15) and combination treatment with lisinopril (30 mg/kg, p.o., q.d., n = 14) was performed for 11 weeks in db/db UNx-ReninAAV mice. Vehicle-dosed (s.c, q.d.) db/db UNx-ReninAAV mice (n = 15) served as controls. *** p < 0.001 vs. vehicle-dosed db/db UNx-ReninAAV mice (Dunnett’s test one-factor linear model with interaction).