Skip to main content
. 2022 Jul 11;10(7):1661. doi: 10.3390/biomedicines10071661

Figure 5.

Figure 5

Semaglutide improves glomerulosclerosis in db/db UNx-ReninAAV mice. Automated AI-based detection of glomerulosclerosis in PAS-positive glomeruli in db/db UNx-ReninAAV mice receiving (q.d.) vehicle, semaglutide (30 nmol/kg, s.c., n = 15) or semaglutide (30 nmol/kg, s.c., n = 15) + lisinopril (30 mg/kg, p.o., n = 14). (A) Group-wise distribution (fraction %) of glomerulosclerosis scores. (B) Glomerulosclerosis index. (C) Fraction of glomeruli with severe or global glomerulosclerosis (GS3 + GS4). (D) Correlation of glomerulosclerosis index and albuminuria. (E) Fractional (%) area of whole-section kidney molecule-1 (KIM-1). (F) Representative photomicrographs from db/db UNx-ReninAAV mice receiving vehicle, semaglutide or combined semaglutide + lisinopril administration. *** p < 0.001 vs. vehicle-dosed db/db UNx-ReninAAV mice; ### p < 0.001 vs. semaglutide (Dunnett’s test one-factor linear model with interaction). Scale bar, 100 µm.