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. 2022 Jul 9;10(7):1654. doi: 10.3390/biomedicines10071654

Figure 3.

Figure 3

Impacts of quercetin-loaded nanoparticles (QT-NPs) therapy on histopathological lesion. Control: healthy non-colitic group (rats orally gavaged with PBS, (a)) showing normal histological structures of columnar epithelial lining mucosa with goblet cells, submucosa, muscular layer and serosal layer. Colitic groups: DSS (rats orally gavaged with dextran sodium sulphate, (b)) showing necrotic lamina epithelialis (arrow) represented by coagulative necrosis of epithelium admixed with leukocytic infiltrates (curved arrow); DSS + QT-NPsI (rats orally gavaged with DSS and quercetin-loaded nanoparticles (QT-NPs at the level 10 mg/kg body weight for 14 days), (c)) showing preserved structures of colon layers with presence of inflammatory cells infiltrates within lamina propria; DSS + QT-NPsII (rats orally gavaged with DSS and quercetin-loaded nanoparticles (QT-NPs at the level 15 mg/kg body weight for 14 days), (d)) showing edema (star) with mildly dilated blood vessels (arrow) within submucosal layer; and DSS + QT-NPsIII (rats orally gavaged with DSS and quercetin-loaded nanoparticles (QT-NPs at the level 20 mg/kg body weight for 14 days), (e)) showing preserved structures of mucosa, submucosa, musculosa and serosa in addition to dilated submucosal blood vessels (arrow). All groups orally gavaged by 3% DSS. Magnification: large micrographs are 100× and smaller ones in the lower left corner are 400×.