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. 2022 Jul 21;10(7):1759. doi: 10.3390/biomedicines10071759

Figure 4.

Figure 4

Effect of R-Carvedilol on calcium wave frequency and properties. The frequency and properties of spontaneous calcium transients or waves were recorded in myocytes after addition of Feno and increasing doses of R-Carv (given below bars). (A) Event frequency. (B) Rate of rise of the calcium signal. (C) Time integral of the calcium signal. Data are from 40 cells/10 patients. p-values were obtained using ANOVA test with Welch correction followed by Bonferroni-adjusted multiple comparisons. Statistically significant differences between pairs of bars are indicated with *: p < 0.05, **: p < 0.01. Solid lines represent fitting using a Hill equation. Circles in (AC) correspond with the values of individual data points.