Figure 1.

Characterization and physical stability of HIM. a) Morphologies of IM and HIM were captured by TEM. Scale bars, 50 nm. b) In vitro releasing behavior of ICG from IM and HIM under pH 7.5/pH 5.4 (n = 3). c) Reduction of singlet oxygen (¹O₂) yield after samples (C _ICG = 10 µg mL⁻¹, C _ADPA = 20 µmol L⁻¹) stored for 6 h (n = 3). Degradation rates of samples during storage (C _ICG = 10 µg mL⁻¹, 25 ℃) d) on day 10 and e) within 10 days. (n = 3). In b, c, and e, data are presented as mean ± standard deviation (SD). For significance analysis, a two‐tailed t‐test (c and e) was performed. NS, no significance **p < 0.01, ***p < 0.001.