. 2022 Mar 28;56(1):84–94. doi: 10.1111/apt.16892

TABLE 2.

Univariate and multivariable predictors of clinical outcome measures in patients with Crohn’s disease

Variable	Medication escalation n = 103 HR (95% CI), p value		Corticosteroid use n = 47 HR (95% CI), p value		Hospitalisation n = 42 HR (95% CI), p value		Surgery n = 26 HR (95% CI), p value
	Univariate	Multivariable	Univariate	Multivariable	Univariate	Multivariable	Univariate	Multivariable
Gender	1.15 (0.78–1.70), p = 0.46		1.25 (0.71–2.23), p = 0.44		0.86 (0.47–1.58), p = 0.63		0.58 (0.26–1.27), p = 0.17
Penetrative versus inflammatory (B2 v sB1)	1.26 (0.81–1.98), p = 0.30		1.34 (0.716–2.52), p = 0.36		2.14 (1.00–4.57), p = 0.050^*	1.63 (0.73–3.67), p = 0.24	3.72 (1.05–13.22) p = 0.042^*	2.16 (0.59–7.98), p = 0.25
Stricturing versus inflammatory (B3 vs. B1)	1.80 (1.07–3.01), p = 0.026^*	1.34 (0.78–2.32), p = 0.28	0.789 (0.327–1.91), p = 0.60		2.67 (1.15–6.19), p = 0.022^*	1.93 (0.80–4.63), p = 0.14	7.25 (2.02–26.02), <p = 0.002^*	4.95 (1.36–18.04), p = 0.015^*
Smoking	1.0 (0.65–1.53), p = 0.10		1.47 (0.81–2.67) p = 0.21		1.22 (0.63–2.35), p = 0.56		2.32 (1.02–5.31), p = 0.045^*	2.05 (0.92–4.55) p = 0.08
Age at diagnosis of CD (y)	0.99 (0.97–1.00), p = 0.06		1.01 (0.99–1.03), p = 0.23		0.99 (0.96–1.01), p = 0.22		0.99 (0.95–1.02) p = 0.35
Disease duration (years from diagnosis to IUS)	1.01 (0.99–1.03), p = 0.26		1.02 (0.99–1.05), p = 0.17		1.03 (1.0–1.06), p = 0.075		1.01 (0.97–1.05), p = 0.74
Baseline Immunomodulator	1.04 (0.70–1.54), p = 0.84		0.41 (0.23–0.74), p = 0.003^*	0.37 (0.20–0.67), p = 0.001^*	1.17 (0.63–2.19), p = 0.62		4.13 (1.42–11.99, p = 0.009^*	3.74 (1.28–10.97), p = 0.016^*
Baseline biologic	1.35 (0.87–2.09), p = 0.18		0.59 (0.33–1.06), p = 0.08		2.79 (1.18–6.63), p = 0.020^*	2.54(1.06‐6.08), p = 0.036^*	3.57 (1.07–11.90), p = 0.038^*	2.41 (0.71–8.18), p = 0.16
Sonographic inflammation	1.95 (1.27–2.98), p = 0.002^*	1.94 (1.23–3.06), p = 0.004^*	2.06 (1.07–3.96), p = 0.031^*	2.41 (1.24–4.67), p = 0.009^*	2.55 (1.22–5.33), p = 0.013^*	2.16 (0.98–4.74), p = 0.06	3.80 (1.31–11.02), p = 0.014^*	2.55 (0.84–7.69), p = 0.10

Significant p < 0.05.