APPENDIX TABLE A2.

Serum and stool biomarkers and clinical complications

	Medication escalation	Corticosteroid use	Hospitalisation	Surgery
	HR (95% CI), p value	HR (95% CI), p value	HR (95% CI), p value	HR (95% CI), p value
Elevated CRP (>5 mg/L)	1.36 (0.83–2.24), p = 0.23	1.00 (0.46–2.13), p = 0.10	1.32 (0.61–2.87), p = 0.48	1.49 (0.57–3.9), p = 0.41
Elevated fecal calprotectin (>250 μg/g)	1.48 (0.76–2.86), p = 0.26	2.22 (0.93–5.29), p = 0.071	1.3 (0.39–4.31), p = 0.67	3.91 (0.77–19.80), p = 0.11
Elevated fecal calprotectin (>150 μg/g)	1.55 (0.081–2.95), p = 0.19	2.11 (0.89–4.98), p = 0.09	1.05 (0.31–3.51), p = 0.93	3.37 (0.66–17.16), p = 0.15
Elevated Fecal Calprotectin (>50 μg/L)	2.29 (1.03–5.06), p = 0.03*	10.7 (0.142–80.48), p = 0.001*	0.55 (0.17–1.59), p = 0.26	3.05 (0.34–26.90), p = 0.26

^* p < 0.05.