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. 2022 Mar 12;64(1):e15072. doi: 10.1111/ped.15072

Table 1.

Summary of the previous reports on the stability of metabolites in stored dried blood spots

Reference Country Samples Sample Number Storage temperature (humidity) Storage period Metabolic markers
Strnadova 15 (2007) Australia Newborns 60 Ambient temperature dry environment 15 years AA, AC
Fingerhut 13 (2009) Switzerland N.D. 10
  • 1.
    −18°C
  • 2.
    18–25°C (25–60%)
 1,000 days AC
Adam 16 (2011) USA Human blood (after adjust of hematocrit) 36
  • 1.
    37°C (<30%)
  • 2.
    37°C (≥90%)
 30 ± 5 days TSH, T4, 17‐OHP, IRT, T‐GAL, GALT、BIOT, SUAC, AA, AC
Prentice 14 (2013) UK Newborns N.D.
  • 1.
    21°C (RT)
  • 2.
    −20°C
  • 3.
    −80°C
 104 weeks AA, AC
Golbahar 17 (2014) Bahrain Newborns N.D.
  • 1.
    RT
  • 2.
    37°C (<30%)
  • 3.
    45°C (<30%)
  • 4.
    37°C (≥70%)
  • 5.
    45°C (≥70%)
 8 days AA, AC
van Rijt 18 (2020) Netherlands Newborns 598

4°C (1st year)

RT (after 2 year)

 5 years AC
The present study Japan newborns 198 5°C 2 years AA, AC
The present study Japan newborns 90 5°C 4 years AA, AC

AA, amino acid; AC, acylcarnitine; BIOT, biotinidase; T‐GAL, total galactose; GALT, galactose‐1‐phosphate uridyltransferase; IRT, immunoreactive trypsinogen; N.D, not described; 17‐OHP, 17α‐hydroxyprogesterone; RT, room temperature; SUAC, succinylacetone; T4, thyroxine; TSH, thyroid‐stimulating hormone.