FIGURE 1.

Effect of asundexian on human FXIa activity in buffer (A; n = 6) and human plasma (B; n = 4). Results are presented as mean ±SEM. Representative thrombograms showing the effect of asundexian on thrombin generation initiated by the FXII activating agent ellagic acid (Actin^® FS) 2.5% (C), or 0.1 pM or 5 pM tissue factor (D and E). Effect of asundexian on clotting time prolongation in human plasma, with the inset expanding the curve for APTT over the asundexian 0–2 μM range (F). Results are presented as mean ±SEM (n = 2___9). APTT, activated partial thromboplastin time; FXIa, activated coagulation factor XI; PT, prothrombin time; SEM, standard error of the mean