Table 3.

The roles of exosomal circRNAs in cancers.

Cancer type	Exosomal circRNAs	Functions of exosomal circRNAs in cancers	References
CRC	circ-ABCC1	Promote CRC progression	[87]
	circ-KLDHC10	Upregulated in serum of CRC patients	[88]
	circ-0004771	Diagnosis and prognosis	[89]
GC	ciRS-133	Promote cancer cachexia, oxygen consumption, and heat production	[90]
	circ-SHKBP1	Promote GC progression	[91]
	circ-RanGAP1	Promote invasion and metastasis	[92]
	circ-0032821	Promote tumor growth	[93]
Glioma	circ-MMP1	Promote the progression of glioma	[94]
HCC	circ-ZNF652	Promote cell proliferation, migration, invasion, and glycolysis	[95]
	circ-100284	Promote the cell cycle	[96]
	circ-DB	Promote tumor cell proliferation	[97]
	circ-100338	Promote HCC metastasis	[98]
	circ- Cdr1as	Promote HCC proliferation and migration	[99]
	circ-0051443	Downregulated in plasma exosomes and tissues from HCC patients	[100]
	circ-PTGR1	Upregulated in serum exosomes from HCC patients	[101]
	circ-UHRF1	Upregulated in human HCC tissues	[102]
	circ-AKT3	Upregulated in exosome from HCC patients	[103]
LSCC	circRASSF2	Promote cancer cell proliferation and migration	[104]
LUAD	circ-002178	Upregulated in the LUAD tissues and LUAD cancer cells	[105]
MM	circ-MYC	Upregulated in exosome from MM patients	[106]
OSCC	circGDI2	Inhibit OSCC cell proliferation, migration, invasion, and glycolysis	[107]
PC	circ-0044516	Promote cell proliferation and metastasis	[108]
PDAC	circ-PDE8A	Promote the invasive growth of PDAC cell	[109]
	circ-IRAS	Promote tumor invasion and metastasis	[110]
UCB	circ-PRMT5	Upregulated in serum and urine exosomes from UCB patients	[111]

CRC, colorectal cancer; HCC, hepatocellular carcinoma; LSCC, laryngeal squamous cell carcinoma; LUAD, lung adenocarcinoma; MM, multiple myeloma; OSCC, oral squamous cell carcinoma; PC, prostate cancer; PDAC, pancreatic ductal adenocarcinoma; UCB, urothelial carcinoma of the bladder.