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. 2022 May 22;9(21):2105868. doi: 10.1002/advs.202105868

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© 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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PAIIR induces influenza‐antigen specific antibody formation. A) Timeline and the plan of the vaccination study: BALB/c mice were vaccinated at D0 followed by a booster at D60, serum was collected at D14, 28 and 75. B) Antigen‐specific serum IgG1 titers at D14, 28 and 75. C) Serum IgG2a titers at D14, 28 and 75. D) Serum IgG1 and IgG2a titers against [II] peptide at D14, D28 and D75. Statistical analysis was done by one‐way analysis of variance (ANOVA) with Tukey's multiple‐comparison test, data shown are mean ± SD ****p < 0.0001, **p < 0.01, *p < 0.1 n = 6 mice.