| Hereditary breast and ovarian cancer: high risk for breast, ovarian and prostate cancers due to DNA changes in genes that include BRCA1, BRCA2 and PALB2 3 |
| Lynch syndrome: high risk for colorectal, endometrial, ovarian and other cancers due to DNA changes in genes that include MLH, MSH2 and MSH6 4 |
| Familial hypercholesterolaemia: increased risk for coronary heart disease due to DNA changes in genes that include LDLR, APOB and PCSK9, causing very high cholesterol levels from an early age 6 |
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