INDEX TEST A. Risk of Bias
Describe the index test and how it was conducted and interpreted:
a) Was the index test or testing strategy result interpreted without knowledge of the results of the reference standard?	Yes / No / Unclear
b) If a threshold was used, was it pre‐specified?	Yes / No / Unclear
c) Were all components and thresholds of multivariable models pre‐specified before their application?	Yes / No / Unclear
d) Were all components of multivariable models defined and assessed ina similar way for all patients (eg in the same healthcare setting)?	Yes / No / Unclear
Could the conduct or interpretation of the index test have introduced bias? High: a) or b) or c) or d) No Low: a) and b) and c) and d) Yes Unclear: not 'high' and a) or b) or c) or d) Unclear	RISK: LOW/HIGH/UNCLEAR