Table 4. Multiple linear regression of various parameters with estimated glomerular filtration rate as the dependent variable after adjusting for potential confounders1) .
| Covariate model | eGFR (mL/min/1.73m2) |
|---|---|
| MDA + confounders | 3.026 (10.400) |
| ox-LDL + confounders | −0.173 (0.124) |
| Homocysteine + confounders | −1.099 (0.286)*** |
| Cysteine + confounders | −0.137 (0.054)* |
| IS + confounders | −1.384 (0.124)*** |
| TEAC + confounders | −0.010 (0.007) |
| GSH + confounders | 0.105 (0.090) |
| GSSG + confounders | 0.019 (0.044) |
| GSH/GSSG ratio + confounders | 96.852 (68.993) |
| GSH-Px + confounders | 0.090 (0.042)* |
| GSH-Px + IS + homocysteine + confounders | 0.003 (0.032) |
| GSH-Px + IS + cysteine + confounders | 0.016 (0.032) |
| Homocysteine + IS + GSH-Px + confounders | −0.290 (0.238) |
| Cysteine + IS + GSH-Px + confounders | 0.017 (0.043) |
| IS + GSH-Px + homocysteine + confounders | −1.328 (0.135)*** |
| IS + GSH-Px + cysteine + confounders | −1.394 (0.135)*** |
| IS + GSH-Px + IS × GSH-Px + homocysteine + confounders | −0.383 (0.363) |
| IS + GSH-Px + IS × GSH-Px + cysteine + confounders | −0.499 (0.378) |
| IS × GSH-Px + IS + GSH-Px + homocysteine + confounders | −0.009 (0.003)** |
| IS × GSH-Px + IS + GSH-Px + cysteine + confounders | −0.008 (0.003)* |
MDA, malondialdehyde; ox-LDL, oxidized low density lipoprotein cholesterol; IS, indoxyl sulfate; TEAC, trolox equivalent antioxidant capacity; GSH, glutathione; GSSG, oxidized glutathione; GSH-Px, glutathione peroxidase; eGFR, estimated glomerular filtration rate.
1)n = 132. Values are β, regression coefficient (SE). Adjusted for confounders (i.e., age, gender, body mass index, albumin, smoking and drinking habits).
*P < 0.05, **P < 0.01, ***P < 0.001.