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. 2022 Jul 25;4(7):901–917. doi: 10.1038/s42255-022-00602-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — a,b, Fluorescent activated cell sorting (FACS) to isolate D2R-expressing neurons (GFP-positive) in the LHA/ZI (a); FGF21 receptor (FGFR1) mRNA is expressed in isolated D2R cells from the LHA/ZI (b). c,d, Effect of injecting an adenoviral vector encoding a scrambled RNA (Ad-hSyn-DIO-EGFP) or an shRNA against D2R (Ad-hSyn-DIO-shD2r-EGFP) in a Cre-dependent manner, followed by ICV injection of vehicle or FGF21 in Vgat-ires-Cre mice on body weight (c) and quantification of immunolabeling for UCP1 in BAT (d). e, Photomicrograph showing the colocalization of Vimentin and GFP in the lateral ventricle.

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