Fig. 6. PSD-based inference of a self-regulatory gene expression model.

A Depicts the self-regulatory gene expression system where the output represses the gene (shown in red) via a nonlinear Hill function (45) with cooperativity coefficient H. B Plots the normalised PSDs (area under the PSD curve is 1) obtained by Padé PSD for various values of H, and compares it with the normalised PSD obtained from experimental single-cell trajectories. The experimental PSD was computed by averaging the PSDs from Q = 100 single-cell trajectories, and the black curve represents the mean, while the shaded grey region represents the symmetric one standard deviation interval around the mean.