This review and meta-analysis assessed the efficacy and safety of intravenous parecoxib administration during the perioperative period for postoperative pain relief following orthopedic surgery in adults.

We included 27 randomized controlled trials comparing intravenous parecoxib with placebo or another active treatment.

Parecoxib relieves postoperative orthopedic pain while sparing opioid analgesic consumption without increasing the incidence of adverse events.

Parecoxib might be an efficacious and safe analgesic in perioperative orthopedic settings.