Fig. 3.

Significantly lower C1M expression in ACR20 responders vs. nonresponders at baseline and weeks 4 and 24. Response was defined by ACR20 (≥ 20% improvement according to the American College of Rheumatology criteria) at week 24. Values are shown as the median (mean is shown as a (plus [+] sign). Boxes represent the interquartile range, while whiskers represent the minimum and maximum values. Asterisk indicates signficant difference at p = 0.0065 between responder and nonresponder defined by fold change ≥ 1.25 and adj p < 0.05