Fig. 7.

Model illustrating the putative pathways that CTPsyn is involved and the crosstalk between these signaling pathways in cancer metabolism. The pro-tumorigenic genes (depicted with *) regulates the assembly of CTPsyn cytoophidia. The de novo nucleotide synthesis is acutely modulated in cancer cells. Glycolysis, tricarboxylic acid (TCA) cycle, amino acid biosynthesis pathways, epidermal growth factor receptor (EGFR), Ras, insulin, and TOR signaling pathways interact with de novo purine and pyrimidine nucleotide synthesis pathways along with the activation of Myc oncogene to increase nucleotide synthesis to cater to the nucleotide dependency of uncontrolled cell proliferation and tissue growth in cancer cells. Created with BioRender.com