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Mechanism of SARS-CoV-2 exploiting CTPS1 for immune evasion, survival, and replication. SARS-CoV-2 suppresses IFN induction upon infection by exploiting host CTPS1 via the deamination of IRF3. SARS-CoV-2 also hijacks the human de novo CTP synthesis for its replication by expressing ORF7b and ORF8 (viral accessory proteins also inhibits IFN induction) that interact and activate CTPS1 (Rao et al. 2021). Created with BioRender.com
