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. 2022 Jul 12;12:937638. doi: 10.3389/fonc.2022.937638

Table 1.

Demographic and clinicopathologic characteristics.

Total PLMR ILMR BILMR
n = 197 Low (133) High (64) P value Low (94) High (103) P value Low (118) High (79) P value
Sex 0.148 0.026 0.575
Female 27 (13.7%) 22 (11.2%) 5 (2.5%) 7 (3.6%) 20 (10.2%) 18 (9.1%) 9 (4.6%)
Male 170 (86.3%) 111 (56.3%) 59 (29.9%) 87 (44.2%) 83 (42.1%) 100 (50.8%) 70 (35.5%)
Age 64.17 62.44 67.77 0.001 66.46 62.08 0.005 64.13 64.23 0.950
±11.05 ± 11.2 ± 9.97 ± 10.9 ± 10.87 ± 11.04 ± 11.2
BMI 23.65 23.63 23.68 0.925 22.7 24.51 < 0.001 23.15 24.39 0.005
±3.04 ± 3.01 ± 3.14 ± 2.87 ± 2.95 ± 2.83 ± 3.22
Smoker 0.092 0.682 0.162
No 140 (71.1%) 89 (45.2%) 51 (25.9%) 65 (33%) 75 (38.1%) 79 (40.1%) 61 (31%)
Yes 57 (28.9%) 44 (22.3%) 13 (6.6%) 29 (14.7%) 28 (14.2%) 39 (19.8%) 18 (9.1%)
Gross hematuria 0.358 0.390 0.294
No 46 (23.4%) 28 (14.2%) 18 (9.1%) 25 (12.7%) 21 (10.7%) 24 (12.2%) 22 (11.2%)
Yes 151 (76.6%) 105 (53.3%) 46 (23.4%) 69 (35%) 82 (41.6%) 94 (47.7%) 57 (28.9%)
Hypertension 0.182 0.682 1.000
No 140 (71.1%) 99 (50.3%) 41 (20.8%) 65 (33%) 75 (38.1%) 84 (42.6%) 56 (28.4%)
Yes 57 (28.9%) 34 (17.3%) 23 (11.7%) 29 (14.7%) 28 (14.2%) 34 (17.3%) 23 (11.7%)
Diabetes 0.529 0.854 1.000
No 172 (87.3%) 118 (59.9%) 54 (27.4%) 83 (42.1%) 89 (45.2%) 103 (52.3%) 69 (35%)
Yes 25 (12.7%) 15 (7.6%) 10 (5.1%) 11 (5.6%) 14 (7.1%) 15 (7.6%) 10 (5.1%)
Tumor size a 0.942 0.045 0.321
<=3cm 110 (55.8%) 75 (38.1%) 35 (17.8%) 45 (22.8%) 65 (33%) 62 (31.5%) 48 (24.4%)
>3cm 87 (44.2%) 58 (29.4%) 29 (14.7%) 49 (24.9%) 38 (19.3%) 56 (28.4%) 31 (15.7%)
Tumor number 0.632 0.466 0.240
Single 86 (43.7%) 56 (28.4%) 30 (15.2%) 38 (19.3%) 48 (24.4%) 47 (23.9%) 39 (19.8%)
Multiple 111 (56.3%) 77 (39.1%) 34 (17.3%) 56 (28.4%) 55 (27.9%) 71 (36%) 40 (20.3%)
WHO grade 0.580 0.383 0.037
Low 55 (27.9%) 35 (17.8%) 20 (10.2%) 23 (11.7%) 32 (16.2%) 26 (13.2%) 29 (14.7%)
High 142 (72.1%) 98 (49.7%) 44 (22.3%) 71 (36%) 71 (36%) 92 (46.7%) 50 (25.4%)
CIS 0.569 0.574 0.868
No 182 (92.4%) 25 (12.7%) 15 (7.6%) 17 (8.6%) 23 (11.7%) 23 (11.7%) 17 (8.6%)
Yes 15 (7.6%) 108 (54.8%) 49 (24.9%) 77 (39.1%) 80 (40.6%) 95 (48.2%) 62 (31.5%)
T stage 0.570 1.000 1.000
Ta 40 (20.3%) 124 (62.9%) 58 (29.4%) 87 (44.2%) 95 (48.2%) 109 (55.3%) 73 (37.1%)
T1 157 (79.7%) 9 (4.6%) 6 (3%) 7 (3.6%) 8 (4.1%) 9 (4.6%) 6 (3%)
Histology 0.981 0.645 0.975
No HV 171 (86.8%) 116 (58.9%) 55 (27.9%) 80 (40.6%) 91 (46.2%) 103 (52.3%) 68 (34.5%)
HV 26 (13.2%) 17 (8.6%) 9 (4.6%) 14 (7.1%) 12 (6.1%) 15 (7.6%) 11 (5.6%)
Recurrence 0.006 0.002 0.448
No 112 (56.9%) 85 (43.1%) 27 (13.7%) 42 (21.3%) 70 (35.5%) 64 (32.5%) 48 (24.4%)
Yes 85 (43.1%) 48 (24.4%) 37 (18.8%) 52 (26.4%) 33 (16.8%) 54 (27.4%) 31 (15.7%)
Progression 0.056 0.009 0.408
No 142 (72.1%) 102 (51.8%) 40 (20.3%) 59 (29.9%) 83 (42.1%) 82 (41.6%) 60 (30.5%)
Yes 55 (27.9%) 31 (15.7%) 24 (12.2%) 35 (17.8%) 20 (10.2%) 36 (18.3%) 19 (9.6%)
a

: For multiple tumors, the diameter of the largest tumor was regarded as tumor size. BMI, Body mass index; WHO, World Health Organization; CIS, Carcinoma in situ; HV, Histological variant; PLMR, Preoperative lymphocyte-to-monocyte ratio; ILMP, Lymphocyte-to-monocyte ratio during induction; PILMR, Preoperative dividing by induction lymphocyte -to- monocyte ratio; n, number.