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. 2022 Jul 12;16:944243. doi: 10.3389/fncel.2022.944243

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Copyright © 2022 Obray, Small, Baldwin, Jang, Lee, Yang, Yorgason and Steffensen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intravenous DA enhances the firing rate of putative DA neurons in the VTA. (A) Representative trace of the firing rate of a putative DA neuron in an experiment in which IV DA was administered. Note the transient, inhibition from baseline (between lines marked in a) of firing rate immediately after the injection (between lines marked b) and the more prolonged increase in firing rate following the transient inhibition (between lines marked c). (B) The firing rate of putative DA neurons was enhanced by domperidone (DOM; 1 mg/kg, IV) pretreatment. (C) The magnitude of inhibition produced by IV DA (3.0 mg/kg, IV) administration was not affected by pretreatment with vehicle (VEH), phentolamine (PHENT), or DOM. (D) However, DOM blocked the enhancement of the DA neuron firing rate produced by IV DA. Phentolamine did not significantly decrease this effect. * indicates p < 0.05.