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. 2022 Mar 29;55(7):1742–1755. doi: 10.1111/ejn.15650

FIGURE 2.

FIGURE 2

NAc mir‐1298‐5p expression during forced abstinence is associated with morphine history. Correlation analyses of calculated ΔΔCt mir‐1298‐5p expression in the NAc with the total number of morphine infusions over 10 days (D) of Self‐administration (SA) after 30D forced abstinence with a relapse test (a) or after 1D forced abstinence with no relapse test (b). The line of best fit is displayed with a dotted line. (c–e) Fold change values of mir‐1298‐5p expression in animals that self‐administered lower or higher amounts of morphine during SA at 30D forced abstinence with a relapse test (c), 1D abstinence with no relapse test (d) and 30D abstinence with no relapse test (e). *p < 0.05. Error ± standard error of the mean (SEM)