TABLE 2.

Recurrent chromosome abnormalities of clinical relevance detected by OGM versus current testing strategy

	Genetic subtype ^a	Recurrent chromosomal abnormality	Case ID	Number of detected variants
	Genetic subtype ^a	Recurrent chromosomal abnormality	Case ID	CBA/FISH/RT‐PCR	OGM
B‐ALL	t(12;21)	t(12;21)(p13;q22) [ETV6::RUNX1]	3;4;10;29	4	4
	t(1;19)	t(1;19)(q23;p13.3) [TCF3::PBX1]	1;13;41	2	3
	BCR::ABL1	t(9;22)(q34;q11) [BCR::ABL1]	15;30	2	2
	BCR::ABL1‐like	t(8;9)(p22;p24) [PCM1::JAK2]	8	1	1
		inv(9)(p24p13) [PAX5::JAK2]	27	0	1
		t(1;5)(q22;q32) [MEF2D::CSF1R]	14	0	1
	CRLF2 rearrangements	t(X;14)(p22.33;q32) [IGH::CRLF2]	38	1	1
	ZNF384 rearrangements	t(12;22)(p13.31;q13.2) [EP300::ZNF384]	2	0	1
	PAX5 rearrangements	dic(9;20)(p13;q11) [PAX5::ASXL1]	39	0	1
		t(3;9)(p13;p13.2) [PAX5::FOXP1]	6	0	1
		ins(9;?)(p13.2;?) [PAX5::ZNF318]	34	0	1
	iAMP21	iAMP21	17	1	1
T‐ALL	TAL1 deregulation	STIL::TAL1	19;23	2	2
	TAL1 deregulation	IGH::TAL1	5	0	1
	LMO2 deregulation	t(11;14)(p13;q11) [TRA::LMO2]	19	1	1
	LMO2 deregulation	t(7;11)(q34;p13) [TRB::LMO2]	22	1	1
	TLX1 (HOX11) deregulation	t(7;10)(q34;q24) [TRB::TLX1]	42	0	1
	TLX3 (HOX11L2) deregulation	t(5;14)(q35;q32) [BCL11B::TLX3]	24	1	1
	HOXA10 deregulation	inv(7)(p15q34) [TRB::HOXA10]	11	1	1
	HOXA10 deregulation	t(7;7)(p15.2;q34) [TRB::HIBADH]	28	0	1
	Subtotal recurrent SVs			17/27	27/27
B‐ALL	Aneuploidy	High hyperdiploidy	7;18;32;35;37	5	5
B‐ALL	Aneuploidy	Low hypodiploidy	12;16	2	1
	Total			24/34	33/34

^{^a}

adapted from Iacobucci I, Mullighan CG. Genetic Basis of Acute Lymphoblastic Leukemia. J Clin Oncol 2017;35(9):975–983.