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. 2022 Mar 30;61(22):e202115805. doi: 10.1002/anie.202115805

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© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Cell viability upon treatment with 1, 1‐Et, 16, 24, 32, and 33. Dose–response curves from cell viability assays of the selected compounds against cultured SKM‐1 (SIRT5‐dependent acute myeloid leukemia) cells and HEK293T (immortalized, non‐malignant human embryonic kidney) cells as well as GI₅₀ values of 1‐Et, 32, and 33 against OCI‐AML2, MOLM‐13 (SIRT5‐dependent acute myeloid leukemia) cells. All values represent data from three individual assays performed in duplicate (see the Supporting Information Figure S9 for additional dose–response curves).