Table 1.
Correlation analysis between related genes and markers of immune cells.
Description | Gene marker | PIK3CA | CDC27 | B2M | PTEN | SMAD4 | IL32 | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | ||
TAMs | CD163 | 0.529 | *** | 0.506 | *** | 0.454 | *** | 0.365 | *** | 0.444 | *** | 0.252 | *** |
CSF1R | 0.424 | *** | 0.332 | *** | 0.424 | *** | 0.364 | *** | 0.397 | *** | 0.190 | *** | |
FCGR2A | 0.404 | *** | 0.420 | *** | 0.462 | *** | 0.302 | *** | 0.312 | *** | 0.364 | *** | |
IL10 | 0.380 | *** | 0.391 | *** | 0.387 | *** | 0.335 | *** | 0.345 | *** | 0.165 | ** | |
VSIG4 | 0.369 | *** | 0.314 | *** | 0.421 | *** | 0.274 | *** | 0.300 | *** | 0.268 | *** | |
CD8+T | CD8A | 0.248 | *** | 0.207 | *** | 0.529 | *** | 0.251 | *** | 0.189 | *** | 0.355 | *** |
CD8B | 0.173 | *** | 0.137 | ** | 0.341 | *** | 0.081 | 0.114 | 0.121 | 0.018 | 0.253 | *** | |
Th1 | CD4 | 0.355 | *** | 0.288 | *** | 0.500 | *** | 0.280 | *** | 0.307 | *** | 0.288 | *** |
STAT4 | 0.437 | *** | 0.362 | *** | 0.478 | *** | 0.342 | *** | 0.344 | *** | 0.319 | *** | |
TBX21 | 0.252 | *** | 0.254 | *** | 0.474 | *** | 0.277 | *** | 0.208 | *** | 0.340 | *** | |
Th2 | CCR4 | 0.420 | *** | 0.318 | *** | 0.354 | *** | 0.338 | *** | 0.338 | *** | 0.184 | |
CCR8 | 0.437 | *** | 0.394 | *** | 0.437 | *** | 0.296 | *** | 0.308 | *** | 0.351 | ||
CXCR4 | 0.383 | *** | 0.260 | *** | 0.326 | *** | 0.277 | *** | 0.277 | *** | 0.073 | ||
GATA3 | 0.211 | *** | 0.057 | 0.267 | 0.317 | *** | 0.257 | *** | 0.086 | 0.093 | 0.129 | ||
Treg | CCR8 | 0.437 | *** | 0.394 | *** | 0.437 | *** | 0.296 | *** | 0.308 | *** | 0.351 | *** |
FOXP3 | 0.254 | *** | 0.219 | *** | 0.393 | *** | 0.165 | ** | 0.220 | *** | 0.327 | *** | |
STAT5B | 0.628 | *** | 0.493 | *** | 0.068 | 0.188 | 0.509 | *** | 0.601 | *** | -0.06 | 0.019 | |
TGFB1 | 0.279 | *** | 0.154 | ** | 0.173 | *** | 0.306 | *** | 0.215 | *** | 0.074 | 0.151 | |
Neutrophils | CCR7 | 0.303 | *** | 0.178 | *** | 0.265 | *** | 0.285 | *** | 0.268 | *** | 0.026 | 0.618 |
CD66b | 0.170 | *** | 0.216 | *** | 0.023 | 0.661 | 0.033 | 0.518 | 0.086 | 0.093 | 0.083 | 0.108 | |
CD11b | 0.467 | *** | 0.346 | *** | 0.371 | *** | 0.357 | *** | 0.335 | *** | 0.229 | *** | |
DCs | CD1c | 0.264 | *** | 0.064 | 0.217 | 0.165 | ** | 0.273 | *** | 0.208 | *** | -0.09 | 0.062 |
ITGAX | 0.449 | *** | 0.403 | *** | 0.419 | *** | 0.323 | *** | 0.320 | *** | 0.311 | *** | |
NRP1 | 0.541 | *** | 0.378 | *** | 0.260 | *** | 0.377 | *** | 0.362 | *** | 0.065 | 0.203 | |
M1 | IRF5 | 0.284 | *** | 0.236 | *** | 0.201 | *** | 0.194 | *** | 0.174 | *** | 0.059 | 0.255 |
NOS2 | 0.035 | 0.5 | 0.145 | ** | 0.146 | ** | 0.056 | 0.277 | 0.107 | * | 0.286 | *** | |
PTGS2 | 0.237 | *** | 0.226 | *** | -0.01 | 0.985 | 0.064 | 0.217 | 0.172 | *** | 0.114 | * | |
M2 | CCL2 | 0.109 | 0.3 | 0.053 | 0.3 | 0.195 | *** | 0.138 | ** | 0.09 | 0.08 | 0.105 | 0.04 |
MS4A4A | 0.416 | *** | 0.351 | *** | 0.506 | *** | 0.329 | *** | 0.324 | *** | 0.278 | *** | |
exhausted T cell | CDC274 | 0.366 | *** | 0.524 | *** | 0.505 | *** | 0.263 | *** | 0.342 | *** | 0.359 | *** |
CTLA4 | 0.296 | *** | 0.328 | *** | 0.412 | *** | 0.194 | *** | 0.289 | *** | 0.313 | *** | |
LAG3 | 0.118 | *** | 0.164 | *** | 0.525 | *** | 0.129 | 0.012 | 0.115 | 0.025 | 0.426 | *** | |
PDCD1 | 0.199 | *** | 0.202 | *** | 0.365 | *** | 0.194 | *** | 0.198 | *** | 0.264 | *** | |
TIGIT | 0.354 | *** | 0.329 | *** | 0.479 | *** | 0.287 | *** | 0.305 | *** | 0.350 | *** | |
GZMB | 0.072 | 0.1 | 0.215 | *** | 0.536 | *** | 0.027 | 0.6 | 0.042 | 0.552 | *** |