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. 2022 Jun 14;6(8):1842–1854. doi: 10.1002/hep4.2012

TABLE 1.

Etiologies of hyperferritinemia

Ferritin >1000 μg/L

  • Infections (HIV and non‐HIV)

  • Malignancy

  • Iron overload

    • ◦

      Primary hereditary hemochromatosis (C282Y homozygous or C282Y/H63D)

    • ◦

      Secondary hemochromatosis (ineffective erythropoiesis or transfusion related)

    • ◦

      Non‐HFE hereditary hemochromatosis

      • ■

        Juvenile Hemochromatosis (HJV‐ hemojuvelin or HAMP‐ hepcidin mutated gene)

      • ■

        TFR2 (transferrin receptor 2)

      • ■

        FPN (ferroportin)

    • ◦

      Aceruloplasminemia

  • Liver dysfunction or disease (alcoholic liver disease, NAFLD, viral hepatitis)

  • Renal Failure

  • Rheumatological conditions

    • ◦

      Adult onset Still’s disease

    • ◦

      Systemic juvenile idiopathic arthritis

  • Hereditary‐hyperferritinemia Cataract Syndrome

 Ferritin >10,000 μg/L

  • Hemophagocytic lymphohistiocytosis (HLH)

  • Adult‐onset Still’s disease

Abbreviations: HAMP, hepcidin antimicrobial peptide; HFE, homeostatic iron regulator; HIV, human immunodeficiency virus; HJV, hemojuvelin.

a

Source: Adapted from Beaton and Adams[ 91 ].