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. 2022 Mar 7;257(1):82–95. doi: 10.1002/path.5871

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© 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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OSM upregulates VEGF expression and release. (A, B) Western blotting time course analysis of (A) P‐ERK1/2 and (B) HIF‐1α on total extracts obtained from HepG2 naïve cells exposed to hrOSM (left panel) or H/OSM (right panel). Equal loading was evaluated by re‐probed membranes for total ERK or α‐tubulin. (C) RT‐qPCR analysis of VEGF mRNA levels in HepG2 naïve cells exposed to hrOSM (left panel) or ELISA assay to quantify human VEGF released by H/OSM (right panel). (D) Western blotting analysis of VEGF released in culture medium by HepG2 naïve cells exposed to hrOSM (left panel) or by H/OSM (right panel).