Figure 2.

Independent genetic variants associated with normal range thyrotropin [thyroid-stimulating hormone (TSH)] in 13 candidate genes. (A) List of included thyroid hormone-regulating candidate genes. Genes with at least 1 independent signal are depicted in bold. (B) The y-axis shows the number of independently associated genetic variants with serum normal range TSH concentrations per gene (x-axis). Only genes with at least 1 significant single nucleotide polymorphism (SNP) association are included. The novel variants are depicted in black, linkage disequilibrium (LD) correlated variants with a genome-wide association study (GWAS) loci outside the candidate gene region in grey and known top hits from GWAS are depicted in a striped pattern.